| How to cite this article: Joob B, Wiwanitkit V. Effect of gold nanoparticle solution on cryptosporidium oocyst: The world first report. Ann Trop Med Public Health 2014;7:192-3 |
| How to cite this URL: Joob B, Wiwanitkit V. Effect of gold nanoparticle solution on cryptosporidium oocyst: The world first report. Ann Trop Med Public Health [serial online] 2014 [cited 2021 Apr 13];7:192-3. Available from: https://www.atmph.org/text.asp?2014/7/3/192/149506 |
Sir,
The usefulness of gold nanoparticle solution as an anti-infective agent is widely discussed. [1] The application in development of new antibacterial drug is mentioned. [1] However, the knowledge of its activity against pathogenic protozoa is limited. Here, the authors perform a preliminary study to assess the effect of gold nanoparticle solution on cryptosporidium oocyst. The authors use the model to assess the effect of gold nanoparticle on cells as previously published papers. [2],[3],[4] Briefly, the author used the confirmed 30 stool samples containing cryptosporidium oocyst for testing. Each stool sample was divided into two parts; naïve manipulation and mixed with 1 cc of gold nanoparticle solution (the solution is prepared as the methods described in the previous study). [2],[3],[4] The authors compared the change of cryptosporidium oocyst count in each group. At the start, the average of the mean cryptosporidium oocyst number per high power field (HPF) was equal to 8.8 ± 1.2 occysts/HPF. The reduction of the mean cryptosporidium oocyst number after test could be observed. The average change after manipulation in naοve and gold nanoparticle solution mixed group equal to 1.2 ± 0.5 occysts/HPF and 4.7 ± 1.2 occysts/HPF., respectively. There is a significant difference in change between two groups (P < 0.05; t-test). This preliminary report might imply that gold nanoparticle solution has the effect against cryptosporidium oocyst. This can confirm the concept that attaching gold nanoparticle to indinavir might help increase its in vitro efficacy against Cryptosporidium parvum. [5] This is the world first report on the antiprotozoal activity of gold nanoparticle.
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Bondioli L, Ludovisi A, Tosi G, Ruozi B, Forni F, Pozio E, et al. The loading of labelled antibody-engineered nanoparticles with Indinsavir increases its in vitro efficacy against Cryptosporidium parvum. Parasitology 2011;138:1384-91.
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Source of Support: None, Conflict of Interest: None
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DOI: 10.4103/1755-6783.149506
