| How to cite this article: Wiwanitkit V, Wiwanitkit S. T cell epitopes within envelope glycoprotein of Ebola virus: The clue for vaccine development. Ann Trop Med Public Health 2015;8:16 |
| How to cite this URL: Wiwanitkit V, Wiwanitkit S. T cell epitopes within envelope glycoprotein of Ebola virus: The clue for vaccine development. Ann Trop Med Public Health [serial online] 2015 [cited 2020 Sep 22];8:16. Available from: https://www.atmph.org/text.asp?2015/8/1/16/156709 |
Dear Sir,
The 2014 Ebola virus epidemic in western Africa is the present concern in global public health. [1],[2] This outbreak is believed to be one of the serious infectious epidemics in history. Generally, Ebola virus infection is a severe viral infection with high mortality. The disease is difficult to control due to lack of vaccination. To create a new vaccine, knowledge on the epitope within the virus molecule is required. Here, the author reports the preliminary assessment to find T cell epitopes within envelope glycoprotein of Ebola virus. The author used the standard immunomincs technique for analysis on the available standard Ebola virus envelope glycoprotein [Accession: Q05320.1, guard interval (GI): 465411] derived from the PubMed database. The details of the immunomics method used in this study are the same as the protocol used in the previously published work by Wiwanitkit. [3] According to the analysis, the nonapeptides starting at position 439, 251, and 502 are the parts that have the highest scores of T cell epileptopigenicity. Interestingly, the derived nonapeptide “STDFLDPAT” is not the same, as previously reported by Wu et al. (“LYDRLASTV”). [4] The data from this study could be the clue for further development of vaccines.
| References |
| 1. |
Reynard O, Volchkov V, Peyrefitte C. A first outbreak of Ebola virus in West Africa. Med Sci (Paris) 2014;30:671-3.
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| 2. |
Gulland A. Health ministers in West Africa hold crisis talks on Ebola virus. BMJ 2014;348:g4478.
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| 3. |
Wiwanitkit V. Finding a T-cell epitope for a melanoma vaccine by an immunomics technique. Asian Pac J Cancer Prev 2006;7:659-60.
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| 4. |
Wu S, Yu T, Song X, Yi S, Hou L, Chen W. Prediction and identification of mouse cytotoxic T lymphocyte epitopes in Ebola virus glycoproteins. Virol J 2012;9:111.
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Source of Support: None, Conflict of Interest: None
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DOI: 10.4103/1755-6783.156709
