| How to cite this article: Wiwanitkit V. T cells epitopes within hemagglutinin of H7N9: A clue for vaccine development. Ann Trop Med Public Health 2013;6:589-90 |
| How to cite this URL: Wiwanitkit V. T cells epitopes within hemagglutinin of H7N9: A clue for vaccine development. Ann Trop Med Public Health [serial online] 2013 [cited 2016 Aug 4];6:589-90. Available from: https://www.atmph.org/text.asp?2013/6/5/589/133756 |
Dear Sir,
The outbreak of H7N bird flu is the present concern in public health. The control of the infection seems to be the aim of a medical practitioner. To control an emerging influenza, one of the most effective ways is to use the vaccination. [1] Nevertheless, as a new emerging infection, there is still no vaccine for H7N9 bird flu. To find the new vaccine is the urgent work at present. In order to produce a new vaccine, the basic vaccine immunology study has to be done. Here, the author uses a simple standard immunoinformatics technique to identify the epitopes within hemagglutinin of H7N9 bird flu. The derived data can be useful for further vaccine development. Briefly, the author use the standard technique as previously published in referencing papers [2],[3],[4] for finding of epitopes within the public available sequence of hemagglutinin of H7N9 bird flu (GenBank: AGI60301.1). The computation tool namely, Major Histocompatibility Complex Predictor version 2.0, [5] was used for finding potential T-cell epitopes. According to the present study, the three parts of the sequences that have the most epitopes activity are LWFSFGASC, EAMGFTYSG and GLFGAIAGF. The derived information can be useful for the next step of vaccine research.
| References |
| 1. | Wiwanitkit V. Current research on drugs and vaccines for fighting bird flu. Trans R Soc Trop Med Hyg 2007;101:1171-2. |
| 2. | Wiwanitkit V. Predicted epitopes of H5N1 bird flu virus by bioinformatics method: A clue for further vaccine development. Chin Med J (Engl) 2006;119:1760. |
| 3. | Wiwanitkit V. Predicted epitopes of Lig A of Leptospira interrogans by bioinformatics method: A clue for further vaccine development. Vaccine 2007;25:2768-70. |
| 4. | Wiwanitkit V. Predicted epitopes of malarial merozoite surface protein 1 by bioinformatics method: A clue for further vaccine development. J Microbiol Immunol Infect 2009;42:19-21. |
| 5. | Guan P, Hattotuwagama CK, Doytchinova IA, Flower DR. MHCPred 2.0: An updated quantitative T-cell epitope prediction server. Appl Bioinformatics 2006;5:55-61. |
Source of Support: None, Conflict of Interest: None
DOI: 10.4103/1755-6783.133756
